Facile One-pot Synthesis of Hollow-structured CuS/Cu₂S Hybrid for Enhanced Electrochemical Determination of Glucose

Abstract

A novel non-enzymatic glucose sensor based on hollow-structured copper sulfide/cuprous sulfide (CuS/Cu₂S) hybrid was developed by using a facile and one-pot solvothermal method. The crystal structure, morphology and surface property of the prepared CuS/Cu₂S hybrid were characterized by X-ray diffraction spectroscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy. The electrochemical performances of this hybrid modified glassy carbon electrode for glucose oxidation were monitored by cyclic voltammograms and amperometric technology. Results showed that the novel integrated electrode exhibited excellent electrocatalytic performances to the oxidation of glucose with a wide line range of 3.0–1100.0 µM, high sensitivity of 321.3 µA mM⁻¹ cm⁻², low detection limit of 1.1 µM (3δ/S), fast response, good anti-interference ability and excellent stability. The proposed sensor was successfully applied for the determination of glucose in human blood serum sample with satisfactory recoveries.