抄録
I injected alloxan of 150-200mg per Kilogramm of body weight intravenously into normal rabbits (asingle injection) and as much into the rabbits which had become normal after diabetic course (2nd injection).
Hemogram, Diameter of erythrocytes, Reticulocyte Count, Heintz's Corpuscles Count, blood sugar curve after insulin and glucose injection glycolytic effort of the blood and so on were investigated.
By these investigations, the Relation between Alloxan and human diabetes, mechanism of Alloan anemia, cause of initial hyperglycemia and generative prossess of Hypoglycemia were discussed as follows.
1. Alloxan anemia seems to be secondary Anemia by blood-toxin, because of Pseudoeosinophil leucocytosis, reticulocytosis, and erythrocyte diameters initial reduction and then enlargement of it.
2. Cause of Initial hyperglycemia seems to be due to hypersecretion of Adrenalin, because of pseudoeosinophil leucocytosis and reduction of erythroyte Diameter, but it is concerning with another factor. (Reticulocytosis is not recognised),
3. Mechanism of Hypoglycemia seems to be due to Insulin hypersecretion.
4. Relation between human diabetes.
i. Analogous Points a. Tendency of lymphocytosis Lymphopenia and abnormality of leucocyte count are symptoms of bad Prognosis.
b. Enlargement of erythrocyte diameter and leaning to the right of Price Jones' curve c. Reticulocytosis d. Glycoregulation disturbance.
e. Sensitiveness upon insulin is recongnised. (On 2nd injection, it is not sensitive in most cases)
f. Glycolytic effort of the blood is repressed during hypeglycemia.
ii. Difterent Points a. easily improvimg tendency b. Glycolytic effort of the blood is promoted when normoglycemia.
