抄録
In 1949, Okamoto found the diabetogenic action of dithizone (diphenyithiocarbazone).
With alloxan diabetes, I had, chiefly from the view-point of the blood findings, reported on its difference from human diabetes, its mechanism of initial hyperglycemia and hypoglycemia, and its generative process of anemia.
I studied, as well, on the dithizone rabbits, whether or not the same facts may be recongnized, and got the following results:
i) Dithizone has a diabetogenic action on the rabbits.
ii) The Diabetogenic action of dithizone is weaker than that of alloxan. Dithizone anemia is less intense than alloxan anemia, in consequence of which the blood toxicity of dithizone is weaker than that of alloxan.
iii) The difference in the blood findings between the rabbits which develop diabetes and those which do not:
Rabbits which develop diabetes……Rabbits which do not develop diabetes.
Initial leukocytes-Count: reduced Some reduced, though its degree slight, some increased.
The phase correspondent to diabetic phase: I ymphocytosis, pseudoeosinophil Leucoc ytosis.
Degree of Anemia: pretty strong slight iv) Initial leucopenia seems to be due to the applied Arnmonium, Lymphocytosis in the diabetic phase should be taken as one of the specific symptom of diabetes.
v) The degree of anemia on the chemical diabetes has probably a close connection with the development of diabetes.
