Abstract
There have been many reports years since on the relationship between diabetes mellitus and reduced gluthathione and S and S-compounds.
I applied “Tibione” (S-compounds) to rats, and in their livers kidneys were found the increase of reduced gluthathione, the decrease of a slight reduction of reduced ascorbic acid and the increase of total reductionscapacity. Consequently I made a study on the influence of “Tibione” on diabetes mellitus, because in cases of diabetes mellitus were frepuently found complications of tuberculosis. The results are summed up as follows:
1) The Influence of “Tibione” on alloxan diabetes!
i) When alloxan was injected into the sats To which “Tibione” had been applied per as prior to the injection, glycosuria was slow to appesr, while at the same time these rats showed a strong resistance to alloxan.
ii) When “Tibione” was injected into the abdominal cairty of alloxan rats, some of them died, while in the survivals glyiosaria did not, at least temporarily, appear.
iii) One case whid of alloxan rats showed the decreasing tendency of blood-sugar when “Tibione” was injected into the rat.
2) The Influeuce of “Tibione” on the pancreatictomyzed cats:
i) When “Tibione” was given to the pancreatictomyzed cats, the appearauce of glycosuria was delayed or not perceived.
ii) Over 2 gramms of “Tibions” given in succession, the time glycosuria was absent as long after the suspension of the application of “Tibione”, in accordame with the period of tratment.
