In 1949, Okamoto found the diabetogenic action of dithizone (diphenyithiocarbazone).
With alloxan diabetes, I had, chiefly from the view-point of the blood findings, reported on its difference from human diabetes, its mechanism of initial hyperglycemia and hypoglycemia, and its generative process of anemia.
I studied, as well, on the dithizone rabbits, whether or not the same facts may be recongnized, and got the following results:
i) Dithizone has a diabetogenic action on the rabbits.
ii) The Diabetogenic action of dithizone is weaker than that of alloxan. Dithizone anemia is less intense than alloxan anemia, in consequence of which the blood toxicity of dithizone is weaker than that of alloxan.
iii) The difference in the blood findings between the rabbits which develop diabetes and those which do not:
Rabbits which develop diabetes……Rabbits which do not develop diabetes.
Initial leukocytes-Count: reduced Some reduced, though its degree slight, some increased.
The phase correspondent to diabetic phase: I ymphocytosis, pseudoeosinophil Leucoc ytosis.
Degree of Anemia: pretty strong slight iv) Initial leucopenia seems to be due to the applied Arnmonium, Lymphocytosis in the diabetic phase should be taken as one of the specific symptom of diabetes.
v) The degree of anemia on the chemical diabetes has probably a close connection with the development of diabetes.

View full abstract

1949, Okamoto reported the oxine (8-oxy.guinoline) rabbits.
As I have investigated on the blood findings of the alloxan and dithizone rabbits, I studied on the oxine rabbits, as well, and had the following results:
i) At the experiment performed in October, the oxine diabetes did not develop by a single injection of diabetogenic dose:
ii) In the blood findings, it brought out a different result from the one found in the blood findings of the alloxan and dithizone rabbits, namely, no peculiar changes as seen in alloxan and dithizone rabbits

View full abstract

It is maintained that tuberculin allergy is generally weak during menstruation, though we have various opinions according to investigator as for whether a not. tuberculin allergy during the periode is variable
In Japan people under 30 years of age should be subjected to the tuberculin test now the tuberculosis prevention law.
I studied to find any differeuce of reaction according to the sexual periode by the tuberculin test with the following results:
i) L found many cases in which the tuberculin reaction was varied by menstruation.
ii) No case was found where positive and negative reactions were mutually converted.

View full abstract

Opinions differ among investigators as to whether or not, the erythrocyte-diameter, is equal between sexes As the subject can't be properly discussed unless it is clarified by women's menstruation, I studied the erythrocyte-diameter of women before, during and after menstruation.
The result is as follows:
i) The erythrocytes-count and hemoglobin-Content have a tendency of diminution during meustrution.
ii) The erythrocyte-diameter is different by menstruation, but the difference is not so much manifest.

View full abstract

There have been many reports years since on the relationship between diabetes mellitus and reduced gluthathione and S and S-compounds.
I applied “Tibione” (S-compounds) to rats, and in their livers kidneys were found the increase of reduced gluthathione, the decrease of a slight reduction of reduced ascorbic acid and the increase of total reductionscapacity. Consequently I made a study on the influence of “Tibione” on diabetes mellitus, because in cases of diabetes mellitus were frepuently found complications of tuberculosis. The results are summed up as follows:
1) The Influence of “Tibione” on alloxan diabetes!
i) When alloxan was injected into the sats To which “Tibione” had been applied per as prior to the injection, glycosuria was slow to appesr, while at the same time these rats showed a strong resistance to alloxan.
ii) When “Tibione” was injected into the abdominal cairty of alloxan rats, some of them died, while in the survivals glyiosaria did not, at least temporarily, appear.
iii) One case whid of alloxan rats showed the decreasing tendency of blood-sugar when “Tibione” was injected into the rat.
2) The Influeuce of “Tibione” on the pancreatictomyzed cats:
i) When “Tibione” was given to the pancreatictomyzed cats, the appearauce of glycosuria was delayed or not perceived.
ii) Over 2 gramms of “Tibions” given in succession, the time glycosuria was absent as long after the suspension of the application of “Tibione”, in accordame with the period of tratment.

View full abstract