アロキサン糖尿病に關する研究

抄録

There are four methods of producing experimental diabetes mellitus in animals. 1) most classic method by pancreatectomy (Mehring, Minkowski) 2) method by repeated injection of pituitary anterior extract (Young, Houssay) 3) method by alloxan injection (Dunn) 4) method by repeated glucose injection of large quantities Dohan ohan, Lukens). Of these, a method which is simplest in technique and lowest in cost is by alloxan, a simple chemical substance, injection, and therefore the pathophysiological studies in alloxan diabetes are conviniently achieved, and in many countries in Europe and America had been often reported but rarely in Japan.
I tried a few tests about pathophysiological changes of rabbits alloxan diabetes mellitus. In every rabbit alloxan injected 200mg/kg intravenouslly after 24 or 36 hours starvation. Results were summarized as follows.