無麻醉犬に於けるアロキサン初期過血糖と副腎との關係に就いて

抄録

In order to determine the relation of the adrenals to alloxan initial hyperglycemia in non-anesthetized dogs, the presnt investigation was performed.
1) All experiments were undertaken in non-anesthetized, non-fastend dogs. Alloxan was given intravenously in a dose of 100mg per kg of body weight..
2) In normal control dogs, the initial hyperglycemia preceded by the slight hypoglycemia, appeared within about an hour after the injection. It arrived at the peak within four hours or so, and proceeded to the following hypoglycemia within about seven hours..
3) When alloxan was injected in non-anesthetized demedullated dogs, the initial hyperglycemia was observed in a magnitude not less than that in the normal control dogs..
4) In two dogs with dorsal spinal roots sectioned previously, the bilateral adrenal glands were removed without anesthesia and alloxan was injected. In one dog a mild hyperglycemia in the initial period was observed, but in the other the same initial hyperglycemia as that in the normal control dogs was found..
5) In the dogs with sectioned dorsal spinal roots, the adrenal venous blood was collected before and after the alloxan injection without narcotizing, fasting, laparotomy or evoking pain. The adrenaline content in the specimens was measured by the rabbit intestine segment method. It was found that the adrenaline secretion rate remained unchanged during the initial hyperglycemic phase. But the augmented adrenaline secretion was observed during the following hypoglycemic phase..
These experimental results signify the fact that the alloxan initial hyperglycemia is not due to the augmented arenaline secretion from the adrenal medulla. Hence, it is concluded that the alloxan initial hyperglycemia is not connected with adrenal medulla.