In this repot we investigated the influences upon the acid-base equilibrium of the adrenalectomized white rabbit.
The right adrenal gland was first removed from the animal and one to two weeks allowed to elapse before the left gland was exstirpated.
Blood was drawn from the auricular vein or the jugular and femoral artery.
Total bicarbonate content determinations of the blood and urine were made according to the Van Slyke technique.
pH determination was made by the glass electrode.
Titratable acidity of the urine was determined by the 0.1N sodium hydroxide with indicator of neutral red.
Urine ammonia content was determined by the Conway's apparatus.
The results run as follows.
1) There is always a fall in pH of blood and urine following adrenalectomy.
2) Bicarbonate content of the blood and urine always decreased.
3) Urine ammonia and titratable acid content increased following adrenalectomy.
4) These results indicate a metabolic type of acidosis, and this acidosis will be more increased by renal failure.
