Clinical Studies on Antidiabetic Action of Mesoxalate

Abstract

The authors have administered calcium mesoxalate 39 times orally for the therapy on 22 diabetics in admission and obtained following results;
(1) It was observed that blood sugar and urinary sugar could be lowered in almost all of the pancreatic and extrapancreatic diabetics by giving daily dose of 0,4-1,5gm of this drug, however, no effect was seen in pluriglandular diabetics.
The effect of calcium mesoxalate against urinary sugar was noticeable than that against blood sugar.
(2) Concerning the relation between the grade of diabetes and the treatment effect of mesoxalate, the effect was more satisfactory on slight and moderate cases than on serious cases.
When we state the word, grade of diabetes, it is classified on the basis of the degree of disturbance of sugar utilization capacity.
(3) Among the cases having no effect by administering mesoxalate only, there were some cases which showed the enhancement of insulin effect when combinated with insulin.
(4) Even a slight dosage of mesoxalate (0,4 gm daily) showed effect on diabetics in general, among cases which had no effect by administration of slight dosage of mesoxalate, there were some cases which had effect by increased dosage.
(5) On almost all of the cases, Meso urinary sugar equivalent for 1gm of Meso. was found less than 3gm.
The effect of 1gm of Meso. corresponded to that of 2,66 units of insulin.
(6) On few cases, impairment of sugar utilization and sugar tolerance capacity were notably improved by Meso. treatment for a period of shorter duration.
(7) The side effect of mesoxalate (0,4-1,5gm daily) was not found in a longer duration. (In a case of treated cases, Meso. was administered as many days as 211 days long)