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Volume 32, Issue 6
Displaying 1-5 of 5 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1956 Volume 32 Issue 6 Pages 410-445
Published: September 20, 1956
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (5587K) -
Yoshitaka KOMORI1956 Volume 32 Issue 6 Pages 446-475,407
Published: September 20, 1956
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe changes of uropepsin levels were estimated after the method of West et al. in the administrations of adrenocorticotropic or adrenal hormone, in various kinds of stress and in insulin response test.
1) The average value of uropepsin in 24-hour urine of Addison's disease was significantly lower than that in healthy controls.
2) The therapeutic minimal dosis of cortisone in Addison's disease caused only a slight increase of uropepsin excretion, while the larger amounts of cortisone induced a significant rise of uropepsin. The therapeutic dosis of cortisone administered in lymphatic leukemia caused a significant elevation of uropepsin.
3) The therapeutic administration of ACTH-gel in nephrotic syndrome caused a significant elevation of uropepsin excretion with the evidences of activation of adrenal cortex, followed by the clinical improvements. Succesive administration of ACTH-gel in the secondary adrenocortical insufficiency complicated in acromegaly induced a gradual increase of uropepsin and urinary total 17-hydroxy-corticods.
4) Eight hour intravenous ACTH infusion test were made with nine subjects and uropepsin changes were observed. The cases of normal adrenal response showed a significant increase of uropepsin, while the cases of insufficient response showed no significant increase.
5) The levels of uropepsin were estimated with 10 cases of primary thoracoplasty, 8 cases of secondary thoracoplasty and 3 cases of laparotomy. The uropepsin levels were definitely elevated after operations in all cases of primary thoracoplasty and laparotomy, and in 6 cases of secondary thoracoplasty. In five cases of surgical operations, parallel estimations of the level of urinary total 17-hydroxycorticoids were made. The levels of urinary total 17-hydroxycorticoids were significantly elevated simultaneously or prior to the increase of uropepsin.
6) In the cases under the other stressors, such as muscular exercise, trauma, exercise in Coni-Island show (rapid shaking of body and psychic tension for fear), and infection of tetanus, the uropepsin significantly increased in the course of stress.
7) The changes of uropepsin levels and circulating eosinophil counts were observed after subcutaneous injection of insulin 0.15 units per kg of body weight. The cases of normal eosinopenic response showed a significant increase of uropepsin after 2 and 4 hours of insulin injection, while the cases of abnormal eosinopenic response showed a definite decrease after 4 hours of insulin injection. The saline injected controls showed no significant increase or decrease of uropepsin.
8) In conclusion, the change of the excretion level of uropepsin has an intimate relationship to the adrenocortical function, which is likely representing one of clinical indexes for stress. Although the increase of adrenocortical hormone in blood may cause the elavation of uropepsin levels, it can not be always concluded that the adrenocortical function to be accentiated in the actual stress with the increase of uropepsin. These uropepsin change is applicable for a useful index in insulin response test, which may afford an available information concerning the activity of hypothalamo-pituitary adrenocortical system.View full abstractDownload PDF (3857K) -
2. The Effect of Pineal Extract upon Blood Sugar Curves Following the Administration of GlucoseMidori IWAMIYA1956 Volume 32 Issue 6 Pages 476-482,408
Published: September 20, 1956
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESS1. It was observed that the hyperglycemia in the rabbit following oral or intravenous administration of glucose was inhibited by an injection of bovine pineal extract, and that such an effect was demonstrable within a certain period of time after the injection of the extract.
2. Administration of thyroid preparation (thyradin) does not have any influences upon the alimentary hyperglycemia-lowering effect of pineal extract.
3. Intravenous injection of a relatively small dose of pineal extract made a result in lowering the glucose tolerance curves immediately after the injection as well as 3 days thereafter.
On the contrary, elevation of the glucose tolerance curves was observed 10 days after the injection.
4. The fasting blood sugar level was slightly lowered by an injection of pineal extract.View full abstractDownload PDF (869K) -
3. The Effect of Pineal Extract upon Blood Sugar Curves Following Administration of Adrenalin or insulin. With Special Reference to the Relationship between Pituitary and Pineal BodyMidori IWAMIYA1956 Volume 32 Issue 6 Pages 483-489,408
Published: September 20, 1956
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIt was found that the pineal extract (bovine) does not only to elevate the adrenalin hyperglycemia, but also to suppress the insulin hypoglycemia in the rabbit.
These effects of pineal extract appeared to continue for a relatively long period of time. Successive administrations of the extract, however, did not result in enhancement of the effect.
It was found that the cerebral extract (bovine) does not have such an action like pineal extract showed.
From these data and the others reported previously, the author reached to the conclusion that the administration of pineal extract might accelerate the pituitary function to secrete growth hormone and/or luteotropin, which in turn will display anti-insulin action.
Following to this new hypothesis, the author attempted to elucidate the apparent discrepancies among the experimental results which were reported previously.View full abstractDownload PDF (926K) -
Masaji TAKEDA, Kyohei NAKANO, Ken FURUBAYASHI, Kenzo WAKABAYASHI, Roku ...1956 Volume 32 Issue 6 Pages 490-500,409
Published: September 20, 1956
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe authors have administered calcium mesoxalate 39 times orally for the therapy on 22 diabetics in admission and obtained following results;
(1) It was observed that blood sugar and urinary sugar could be lowered in almost all of the pancreatic and extrapancreatic diabetics by giving daily dose of 0,4-1,5gm of this drug, however, no effect was seen in pluriglandular diabetics.
The effect of calcium mesoxalate against urinary sugar was noticeable than that against blood sugar.
(2) Concerning the relation between the grade of diabetes and the treatment effect of mesoxalate, the effect was more satisfactory on slight and moderate cases than on serious cases.
When we state the word, grade of diabetes, it is classified on the basis of the degree of disturbance of sugar utilization capacity.
(3) Among the cases having no effect by administering mesoxalate only, there were some cases which showed the enhancement of insulin effect when combinated with insulin.
(4) Even a slight dosage of mesoxalate (0,4 gm daily) showed effect on diabetics in general, among cases which had no effect by administration of slight dosage of mesoxalate, there were some cases which had effect by increased dosage.
(5) On almost all of the cases, Meso urinary sugar equivalent for 1gm of Meso. was found less than 3gm.
The effect of 1gm of Meso. corresponded to that of 2,66 units of insulin.
(6) On few cases, impairment of sugar utilization and sugar tolerance capacity were notably improved by Meso. treatment for a period of shorter duration.
(7) The side effect of mesoxalate (0,4-1,5gm daily) was not found in a longer duration. (In a case of treated cases, Meso. was administered as many days as 211 days long)View full abstractDownload PDF (1130K)
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