Abstract
A 43 year old male who was admitted to the Second Department of Internal Medicine of the Kyushu University Hospital because of general malaise and headache. Clinically he had moon-face, trucial obesity with buffalo-hump, cutaneous striae and edema, osteoporosis, polycythemia, eosinopenia, polyuria, albuminuria, glycosuria with hyperglycemia, hypokaliemia and hypocalcemia. Serum total cholesteral 316mg/dl and urinary 17-Ketosteroid excretion 35mg/24 hours.
Postmortem examination revealed adenocarcinoma of bilateral adrenal corteces with pulmonary metastasis, Crooke's change of pituitary basophil cells, atrophy of Langerhans' islets, thyroid, parathyroid and testes. There was also intercapillary glomerulosclerasis.
