Abstract
Paper electrophoresis studies were made on the serum protein fractions in rabbits given powdered thyroid gland (30 mg/kg every day, per os) or undergoing thyroidectomy, and in the offspring of rabbits (F1, F4, F5 ; these were not given powdered thyroid gland nor did they undergo thyroidectomy) descended from ancestors given powdered thyroid gland (30 mg/kg every day for one month, per os) or undergoing thyroidectomy (more than one month after operation) over several successive generations. Compared with normal values, the results were as follows.
1) Average values in 8 normal rabbit sera (4 female, 4 male) were ; albumin 60.7±1.7%, a-globulin 13.0 ±2.0%, β-globulin 12.2 ±2.1% and γ-globulin 14.1±1.9%. Total protein values were 6.39±0.24g/d1.
2) Alterations presented with the passage of time after the administration of powdered thyroid gland in normal rabbits were, albumin was markedly decreased, a-globulin and γ-globulin increased after 10 days and after that continued similar changes. Changes after thyroidectomy schowed gradually a decrease in albumin and an increase in β-globulin, and these findings became more evident as time passed.
3) Serum protein fractions in offspring of rabbits (F1, F4, F5) administered powdered thyroid gland over successive generations showed a decrease in albumin and an increase in a-globulin, and these changes seemed more and more evident as the generations progressed, and resembled the values in rabbits given powdered thyroid gland.
4) Serum protein fractions in offspring of rabbits (F1, F4) undergoing thyroidectomy over successive generations showed a decrease in albumin, a slight increase in α-globulin and an increase in β-globulin. These changes also seemed more evident as the generation progressed, and resembled the values of rabbits after thyroidectomy.
