抄録
We examined the method of computing urinary 17KGS in accordance with the Appleby-Norymberski method (1955), improved on the method of excluding imporitities in the urinary extract, and confirmed definitely that various corticoids were converted 17KS.
By applying this modified Appleby-Norymberski method clinically, we obtained new interesting knowledge.
Results are as follows :
(1) Secrosterone (6α-21-dimethy1-17α-ethinyl-testosterone) and testosterone are not transformed into 17KS, consequently, estimation values are not affected by them.
(2) Average amounts of urinary 17KGS excretion of 32 amenorrhoic females and 32 normal females were 5.7 mg and 4.5 mg, respectively. Values of amenorrhoic females were usually in the higher part of normal range.
(3) Metabolism of corticoids was accelerated in the latter half of the menstration cycle.
(4) Levels of urinary 17KGS of pregnancy are considerable above the normal range and that in the first trimester of pregnancy are in high rate, but in comparatively low rate in the latter half, because metabolism of steroids is inhibited by estrogen at that time.
(5) In cases which were administered with 17α-OH-progesterone Capronate, urinary total 17KGS levels increased. But 17KS and its fraction were not changed remarkably. Urinary 17KGS decreased with the administration E.P. (17α-ethynyl-testosterone ; ethinyl estradiol), and had no change with the administration of secrosterone and 0.5 mg Dexamethazone and less.
This method is useful for the clinical examinations of subclinical adrenal disorder and hypermetabolism which has not been found by the Poter-Silber method.
