交感神経活動の指標としての血中norepinephrineと3, 4-dihydroxyphenylglycolの同時測定

抄録

A high performance liquid chromatographic method with electrochemical detection is described for simultaneously measuring the concentrations of the endogeneous catecholamines and the deaminated catecholamine metabolite 3, 4-dihydroxyphenyglycol (DHPG) in plasma. Plasma DHPG concentrations as determined by the present method were734±77pg/ml after 30 min. of supine rest whereas plasma norepinephrine (NE) concentrations were 114±20pg/ml in 5 healthy subjects. The DHPG and NE concentrations increased to 891±64 and 266±36pg/ml, respectively, after 30 min. of upright position following 30 min. of supine rest. The simultaneous measurement of plasma DHPG and NE concentrations may provide a more comprehensive assessment of the sympathetic nervous system.