膵のインスリン, グルカゴン, ソマトスタチン放出に及ぼすgrowth hormone-releasing factor (GRF) の影響
-ラットの摘出膵灌流による-
1990 年 66 巻 5 号 p. 557-571
詳細
1990 年 66 巻 5 号 p. 557-571
To examine the effects of growth hormone-releasing factor (GRF) on islet hormone release, rat pancreas was perfused. rhGRF at the concentration of 10-7M or more enhanced insulin secretion stimulated by 16.7mM glucose, hpGRF slightly enhanced insulin secretion as well. The insulin secretion induced by 10-6M rhGRF was completely inhibited by 10-6M propranolol. rhGRF at the concentration of 10-8M or more stimulated glucagon secretion even in the presence of 16.7mM glucose. The glucagon secretion stimulated by 10-6M rhGRF was inhibited in the early period but increased thereafter by 10-6M propranolol. 10-6M rhGRF slightly stimulated glucagon secretion in the presence of 16.7mM glucose when STZ diabetic rat pancreas was perfused. rhGRF at the concentration of 10-6M enhanced somatostatin secretion stimulated with 16.7mM glucose.
We concluded that rhGRF stimulated insulin, glucagon and somatostatin secretion and the insulin secretion was inhibited by β-blocker. hpGRF stimulated insulin and glucagon secretion as well.
