抄録
We describe a case of central diabetes insipidus deteriorating NIDDM. A 42-year-old male visited our hospital's outpatient department with complaints of xerostomia, polydipsia and polyuria, and was found to have hyperglycemia and glycosuria in spite of a small quantity of urinary specific gravity.
He was immediately diagnosed as diabetes mellitus, and treated with insulin and a restricted caloric intake. His blood sugar level came under control, however his urinary specific gravity remained low with a volume of about 5,000ml/day.
Diabetes insipidus was suspected. His pituitary gland was examined. The failure of antidiuretic hormone (ADH) release was revealed by water deprivation and hypertonic saline tests.
The functions of the anterior lobe were normal; and an MRI study of the pituitary gland showed that the sella turtica had neither tumor nor high intensity area of the T1-weighted image which was suggested in the posterior lobe.
The male was diagnosed as idiopathic central diabetes insipidus, and subsequently treated with DDAVP. bringing his urinary specific gravity within normal levels. His blood sugar level was controlled and normal without insulin. Dehydration from the diabetes insipidus is suspected to have deteriorated the NIDDM and to have caused the hyperglycemia.
