Abstract
C14-incorporation into blood glucose and liver glycogen from C14-labelled alanine was studied in rats with acute or chronic CCl4 liver damage.
In rats with CCl4 liver damage, C14-incorporation from alanine into blood glucose and liver glycogen was found to be decreased, especially in rats with acute CCl4 liver damage. Such a disturbed C14-incorporation was improved by the administration of 2.5mg of cortisone to rats with chronic CCl4 poisoning. However, in rats with acute CCl4 liver damage, cortisone treatment caused a marked increase in C14-incorporation into blood glucose and failed to increase C14-incorporation into liver glycogen.
The latter finding may be related to the increased incidence of steroid diabetes in patients with liver damage.
