Endocrine Journal
Our official Japanese journal "Naibunpigaku Zasshi" was first issued in 1925 and renamed as "Nihon Naibunpigaku-kai Zasshi" in 1927. In 1954 the first issue of English official journal "Endocrinologia Japonica" was published continuing to Volume 39 in 1992 and then renamed as the present "Endocrine Journal" from Volume 40 in 1993.
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Published by The Japan Endocrine Society  
6,392 registered articles
(updated on June 03, 2023)
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
2021 Journal Impact Factor (JIF)
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Featured article
Volume 70 (2023) Issue 5 Pages 465-472
Glucose and lipid metabolisms in human endometrial stromal cells during decidualization Read more
Editor's pick

Reproductive endocrinology provides us with a lot of tips in a various area of medical science. In this issue, Dr. Tamura and colleague contribute an insightful review article focusing on glucose and lipid metabolism in human endometrial stromal cells during the course of decidualization. To effectively supply energy for embryo, human endometrial stromal cells aggressively ingest fuel via GLUT1 and VLDL receptor under the transcriptional control and epigenetic modification involved in C/EBP beta, p300 and WT1. Such a fashion would be reminiscent, at least in part, of fuel metabolism commonly seen in cancer cells. It is also anticipated that energy metabolism-based unique approach in this article opens a fresh avenue for cutting edge medicine and therapeutics on incomplete implantation or infertility.

Volume 70 (2023) Issue 4 Pages 343-358
Neuroendocrine regulation of reproduction by GnRH neurons: multidisciplinary studies using a small fish brain model Read more
Editor's pick

As well known, comparative endocrinology has long provided deep insight into pathophysiology and molecular basis of a variety of human endocrinologic diseases. In this issue, by use of a small fish model, Dr. Yoshitaka Oka contributes an extensive, well-organized article on the recent research progress in neuroendocrine regulation of reproduction by GnRH neurons, providing us with an invaluable perspective for cutting-edge area of reproductive endocrinology in humans.

Volume 70 (2023) Issue 3 Pages 295-304
Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency Read more
Editor's pick

It is well recognized that a line of symptoms of neurohypophyseal diabetes insipidus (NDI), also known as arginine vasopressin (AVP) deficiency, are masked under the condition of adrenal insufficiency. However, molecular mechanisms whereby polyuria manifests after the administration of glucocorticoids in patients with masked NDI have not been fully elucidated. Kurimoto J and colleague elegantly solved this long-lasting enigma via comprehensive analyses including patients with masked NDI as well as murine model of familial NDI. They provide a convincing proof that mineralcorticoids directly attenuate the expression of aquaporin-2 in the apical membrane of collecting duct, thereby leading to the increase in urine volume in patients with NDI.

Volume 70 (2023) Issue 1 Pages 69-76
Clinical characteristics and efficacy of pioglitazone in a Japanese patient with familial partial lipodystrophy due to peroxisome proliferator-activated receptor γ gene mutation Read more
Editor's pick

To date, familial partial lipodystrophy (FPLD) has been known to consist of seven types, and FPLD type 3 is a rare autosomal dominant genetic disorder caused by mutations of peroxisome proliferator-activated receptor γ gene. In this issue, Dr. Iizaka and colleague report the first pedigree of FPLD 3 in Japanese exemplifying prolonged insulin resistant diabetes mellitus, liver steatosis and hypertriglyceridemia with a relatively low degree of BMI and percentage of body fat. For all endocrinologists, attention should be paid to avoid overlooking lipodystrophy syndromes.

Volume 69 (2022) Issue 11 Pages 1285-1293
Thyrotropin receptor antagonists and inverse agonists, and their potential application to thyroid diseases Read more
Editor's pick

Molecular research on agonists / antagonists / inverse agonists in a variety of G-protein coupled receptors (GPCRs) has long attracted robust attention of endocrinologists. In this issue, Dr. Nagayama and Dr. Nishihara contributes an encyclopedic, well-organized article on the update of antagonists / inverse agonists research around the thyrotropin receptor (TSHR), providing us with promising therapeutic potential for Graves’ hyperthyroidism, non-autoimmune hyperthyroidism, thyroid cancer and resistance to thyroid hormone.

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