Abstract
An attempt has been made to produce experimental cancer in the prostate of Wistar strain male rats by local administration of 20-methylcholanthrene (MC), thereby evaluating the incidence of neoplasmas, changes in activities of LDH and ALP, DNA metabolism and in the LDH isozymes pattern as well as the influence of sex hormones upon them. The following are the results obtained: 1) While estradiol benzoate (Eb) increased the incidence of prostatic neoplasmas, testosterone propionate (Tp) inhibited it. 2) DNA metabolism, especially the tritium index, was stimulated by Eb, whereas it was inhibited by Tp. 3) LDH activity was inhibited by Eb and promoted by Tp.As for the effects on the LDH isozymes pattern, Eb decreased the proportion of the M type, while Tp increased it. 4) ALP activity was somewhat suppressed by Eb administration.
