Abstract
Serum FSH and LH levels were measured serially by radioimmunoassay in fifteen menstrual disordered or infertile subjects for two menstrual cycles, one control cycle and another cycle treated with clomiphene citrate. Lack of normal cyclic patterns that usually appear in ovulatory individuals of serum FSH and LH, however, within the range of normal levels in most subjects, as well as the day-to-day fluctuation of gonadotropin levels were observed in amenorrheic or anovulatory patients. By regarding the early rise of gonadotropins after clomiphene intake as a favorable response, those with fluctuating gonadotropin levels during untreated cycle were found to respond considerably to clomiphene citrate. Thus, a predictability is suggested. In the clomiphene-induced ovulatory cycles the serum FSH and LH exhibited either similar to those usually seen in normal ovulatory cycle or without a sequence of normal pattern but midcycle surge. The discordancy of gonadotropins stimulated by clomiphene which suggested the cause of temporal failure with this medicine was pointed out.
