Abstract
1) Three hundred and fifteen mg. of TSH-like substance has been obtained from 350g. of human placenta by Loeser's method. Sixty-one mg. of the similar substance has been extracted from 900g. of placenta by Ciereszko's method.
2) By the administration of this TSH-like substance to guineapigs, an elevation of the PBI level and a decrease in serum cholesterol were caused.
3) Distinctly hypertrophied and columnar cells of the epithelium of follicles, small amount of colloid in the follicles, dilatation of capillary nets in the guineapigs thyroid glands were observed histologically after administration of the TSH like substance.
4) We propose the name P-TSH (placental thyroid stimulating hormone) for this substance.
