Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
5α-Dihydrotestosterone “Receptor” in the Rat Hypothalamus
JUNZO KATOTSUNEKO ONOUCHI
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1973 Volume 20 Issue 4 Pages 429-432

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Abstract
A 5α-dihydrotestosterone binding component, sedimenting with a sedimentation constant of 8.6S, was detected in rat hypothalamic cytosol labelled in vitro with 5α-dihydrotestosterone-3H. The dissociation constant of the androgen-protein complex and the number of binding sites of the component were approximately 7.4×10-10M and 0.9×10-14 moles/mg cytosol protein, respectively. The binding component seemed to have a specificity for 5α-dihydrotestosterone relative to other hormones. These results suggest that the cytosol from male rat hypothalamus contains “receptor” for 5α-dihydrotestosterone.
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© The Japan Endocrine Society
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