Abstract
Spontaneous ovulation was inhibited in female rats with isocarboxazid (IC), MAO-Inhibitor. Administration of HCG to IC-treated females at 3:00p.m. on the day of proestrus induced ovulation. Although the brain serotonin level was still high (1.5 times the control) from 9:00a m. to 6:00p.m. on the next day after IC-injection, ovulation occurred on the second day morning. Female rats, with the increased brain serotonin level by IC-injection, copulated on the afternoon of proestrus, and ovulation occurred in the mated animals on the next morning. These results indicate that the stimulus provided by mating may overcome the inhibitory effects of serotonin in IC-treated females.
