The Effect of a Spleen Dialysate on the Enzymatic Pattern of the Rodent Ovary

Abstract

The stimulating effect of a spleen dialysate on the testicles and the accessory genital organs motivated the authors to test this dialysate on the ovaries. Also on the ovaries a different influence was observed.
In comparison to the control animals, the enzyme pattern: lactate dehydrogenase, steroid-3-β-ol-dehydrogenase, alkaline phosphatase, succinate dehydrogenase, and, glucose-6-phosphate-dehydrogenase is significantly changed. The effect is manifested by an increase of the tertiary follicles, increased follicular atresia and disquamating granulosa. On the basis of these findings we assume that the spleen dialysate is able to increase the gonadotropin effect on the ovaries.