Effect of Somatostatin (Growth Hormone Inhibiting Factor: GIF) on TRH-induced TSH Release in Rats

MASAFUMI UTSUMI; HIROYUKI MAKIMURA; AKIHISA YAMADA; MAKOTO TATEIWA; HIDETARO MORI; TAKAAKI KUSAKA; MASAHIRO SAKODA; SHIGEAKI BABA

doi:10.1507/endocrj1954.21.449

MASAFUMI UTSUMI, HIROYUKI MAKIMURA, AKIHISA YAMADA, MAKOTO TATEIWA, HIDETARO MORI, TAKAAKI KUSAKA, MASAHIRO SAKODA, SHIGEAKI BABA

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MASAFUMI UTSUMI
Second Department of Internal Medicine, Kobe University, School of Medicine
HIROYUKI MAKIMURA
Second Department of Internal Medicine, Kobe University, School of Medicine
AKIHISA YAMADA
Second Department of Internal Medicine, Kobe University, School of Medicine
MAKOTO TATEIWA
Second Department of Internal Medicine, Kobe University, School of Medicine
HIDETARO MORI
Second Department of Internal Medicine, Kobe University, School of Medicine
TAKAAKI KUSAKA
Second Department of Internal Medicine, Kobe University, School of Medicine
MASAHIRO SAKODA
Second Department of Internal Medicine, Kobe University, School of Medicine
SHIGEAKI BABA
Second Department of Internal Medicine, Kobe University, School of Medicine

JOURNAL FREE ACCESS

1974 Volume 21 Issue 5 Pages 449-452

DOI https://doi.org/10.1507/endocrj1954.21.449

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Abstract

Intravenous preadministration of somatostatin (Growth Hormone Inhibiting Factor: GIF) inhibited TRH-induced TSH release in rats anesthesized by pentobarbitulate. There was dose dependent negative interaction between the inhibitory effect of GIF and releasing effect of TRH. TSH releasing effect of small dose of TRH was inhibited completely by preadministration of GIF, while large dose of TRH overcame the inhibitory effect of GIF. The mechanism responsible for inhibitory effect of GIF on TRH-induced release was discussed.

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