Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Dual Effect of Clomiphene Citrate on Pituitary Gonadotropin Secretion in Postmenopausal Women
TAKUMA HASHIMOTOKIYOSHI MIYAIKANJI IZUMITOSHIO ONISHIYUICHI KUMAHARA
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1976 Volume 23 Issue 2 Pages 115-118

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Abstract
Fifteen postmenopausal women were given 25mg, 50mg of clomiphene citrate daily by mouth for 3 consecutive days. Significant (p<0.01) decrease of serum LH (73%, 65%) and FSH (76%, 76%) resulted after administration of 25mg and 50mg clomiphene citrate respectively. The suppressive effect was sustained for at least 4 days after cessation of this drug.
On the other hand decreased LH and FSH levels after administration of ethinyl estradiol increased again by simultaneous administration of clomiphene citrate. These results suggest that estrogenic effects of clomiphene citrate are observed in untreated estrogen deficient subjects but anti-estrogenic effects are evident when serum estrogen levels are restored in subjects with estrogen deficiency.
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© The Japan Endocrine Society
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