Abstract
Synthetic thyrotropin-releasing hormone (TRH) tartrate monohydrate was administered by rapid intravenous injection to nine normal males. Plasma thyroid-stimulating hormone (TSH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured before and at selected periods after TRH injection. The mean plasma TSH value immediately prior to TRH injection was 3.5μU/ml and the level 15 min after injection was 14.8μU/ml. The mean plasma LH value immediately prior to TRH injection was 8.0mIU/ml and the level 15 min after injection was 15.0 mIU/ ml. The latter elevation was statistically significant (p<0.01), although it was just above the upper normal range. The mean plasma FSH value immediately prior to TRH injection was 7.7 mIU/ml, and a significant difference was not observed after TRH administration. These results revealed that synthetic TRH tartrate monohydrate influenced the release of LH from the anterior pituitary.
