Effect of Cytidine Diphosphate Choline on Growth Hormone and Prolactin Secretion in Man

Abstract

The effect of intravenous infusion of cytidine diphosphate choline (CDP-choline) on the serum levels of growth hormone (GH) and prolactin (PRL) was studied in six normal adult male subjets. Serum GH levels increased and reached a maximum at 60-90min after the initiation of infusion in all subjects examined. The mean peak value of GH in six subjects was 10.0±2.1 (mean±SE) ng/ml, which was significantly higher than the basal level (p<0.01). In four subjects, serum PRL levels decreased from 10-24ng/ml to less than 7.2 ng/ml at 60-120 min, while in the other two no significant change was observed. These results indicate that CDP-choline affects GH and PRL secretion from the anterior pituitary.