1980 Volume 27 Issue 6 Pages 675-678
Changes in somatostatin levels in portal plasma in response to intragastric glucose loading were examined in normal controls and streptozotocin diabetic rats of one week duration.
The mean (±SEM) basal level of somatostatin was more significantly elevated in diabetic rats (401±62 pg/ml) than in controls (171±13 pg/ml). However, no significant difference in somatostatin concentrations 30 min after glucose loading was found between diabetic and control animals (587±113 vs. 443±47 pg/ml). Glucose loading caused a significant elevation of somatostatin in controls, but not in diabetic rats.
These results suggest a physiologic role of somatostatin in nutrient homeostasis, and that abnormalities in D cell function are present in streptozotocin diabetes of short duration.
