HLA-DR Antigens in Japanese with Hashimoto's Thyroiditis and Graves' Disease

YOSHIE AZUMA; TAKEHIKO SAKURAMI; YUKIO UENO; MARIKO OHISHI; HIROO SAJI; PAUL I. TERASAKI; MIN S. PARK; SSHIRLEY LOUIE; STEVE TAKEMURA

doi:10.1507/endocrj1954.29.423

YOSHIE AZUMA, TAKEHIKO SAKURAMI, YUKIO UENO, MARIKO OHISHI, HIROO SAJI, PAUL I. TERASAKI, MIN S. PARK, SSHIRLEY LOUIE, STEVE TAKEMURA

Author information

YOSHIE AZUMA
Department of Internal Medicine, National Kyoto Hospital
TAKEHIKO SAKURAMI
First Division of Internal Medicine, Shimane Medical University
YUKIO UENO
Second Division of Internal Medicine, Faculty of Medicine, Kyoto University
MARIKO OHISHI
Department of Internal Medicine, National Kyoto Hospital
HIROO SAJI
The Kyoto Red Cross Blood Center
PAUL I. TERASAKI
Department of Surgery, School of Medicine, University of California
MIN S. PARK
Department of Surgery, School of Medicine, University of California
SSHIRLEY LOUIE
The Kyoto Red Cross Blood Center
STEVE TAKEMURA
The Kyoto Red Cross Blood Center

JOURNAL FREE ACCESS

1982 Volume 29 Issue 4 Pages 423-427

DOI https://doi.org/10.1507/endocrj1954.29.423

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Abstract

HLA-A, -B, -C and -DR specificities were determined to study the association of HLA in 49 unrelated patients with Hashimoto's thyroiditis and 51 patients with Graves' disease. The results were compared with 144 control subjects from the Japanese population at large. Much less HLA-DR2 was found in the patients with Hashimoto's thyroiditis than in the normal controls. It was present in 16% of the thyroiditis patients compared to 39% in the controls. Also the frequency of HLA-DR1 was less in the patients with Graves' disease (0%) than in the controls (15%). No positive association was found for any HLA-antigens in the two diseases.

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