Suppressive Effect of Elcatonin, an Eel Calcitonin Analogue, on Excessive Urinary Hydroxyproline Excretion in Polyostotic Fibrous Dysplasia (McCune-Albright's Syndrome)

Abstract

A 12-year-old Japanese girl with polyostotic fibrous dysplasia and endocrine concomitants, was treated with elcatonin, a synthetic eel calcitonin analogue, 10 MRC unit/twice a week given by intramuscular injection. Significant decreases in 24 hr urinary content of hydroxyproline and other amino acids from bone collagen were observed during the course of treatment over 5 months. This biochemical result suggests that the synthetic eel calcitonin analogue exhibits the therapeutic effect in patients with polyostotic fibrous dysplasia by inhibiting bone resorption.