Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Comparison of LATS Activity and TSH Receptor Antibody in Graves' Disease
YOSHIHIRO KAJITAYOSHIYUKI NAKAJIMAMASAO ISHIDAYASUAKI URAYUKIO OCHITADAYOSHI MIYAZAKITAKASHI HACHIYAHAMAO IJICHI
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1984 Volume 31 Issue 3 Pages 369-374

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Abstract
TSH-receptor antibody (TRAb) activity and LATS activity of Graves' sera were compared. All of 50 LATS-positive cases were TRAb positive, although only 63% of LATS-negative cases were TRAb positive.
Binding of 125I-TSH to the TSH receptors was inhibited dose-dependently by LATS-immunoglobulin. However, no correlation between TRAb activity and LATS activity was observed.
TRAb was positive in 2 LATS-positive cases even when the symptoms of hyperthyroidism were controlled by treatment (antithyroid or radioisotope). The positive TRAb was not changed in 4 Graves' disease patients whose LATS activity had disappeared following antithyroid treatment. These clinical studies show that TRAb is more sensitive than LATS and suggest that LATS may be one of a heterogenous population of antibodies to the TSH receptor in Graves' disease.
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© The Japan Endocrine Society
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