Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Bioconversion of Arachidonic Acid by Human Uterine Cervical Tissue and Endocervix in Late Pregnancy
NAOKI MITSUHASHIJUNZO KATO
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1984 Volume 31 Issue 5 Pages 533-538

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Abstract
Prostaglandins (PGs) may play an important role on cervical ripening in late pregnancy, namely cervical dilatation and softening. To investigate this, arachidonic acid metabolites of cervical tissue and endocervix were studied. To separate and identify the metabolites, silicic acid chromatography, thin layer chromatography, reversed phase chromatography, gas-liquid chromatography and GC-MS were used. In cervical tissue, arachidonic acid was converted to 6-ketoPGF, PGF, PGE2, thromboxane B2, and 12-HETE. In endocervix, arachidonic acid was converted to PGF, PGE2, thromboxane B2, 12-hydroxy-5, 8, 10-heptadecatrienoic acid, and 12-HETE. There was no relation between the arachidonic acid conversion rate and the Bishop score (points of cervical ripening).
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© The Japan Endocrine Society
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