Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Cardiac Performance and Coenzyme Q10 in Thyroid Disorders
HITOSHI SUZUKITAKESHI NAITOHSUMIO KUNIYOSHINOBUYUKI BANBAHISAMOTO KURODAYOSHINOBU SUZUKIMASAKI HIRAIWANORIKO YAMAZAKIMAKOTO ISHIKAWAYOSHIHISA HASHIGAMINORIO KASEHIROHUMI KOBORIKIKUO KASAISHIN-ICHI SHIMODA
Author information
JOURNALS FREE ACCESS

1984 Volume 31 Issue 6 Pages 755-761

Details
Abstract

To investigate the relationship between serum levels of Coenzyme Q10 and cardiac performance in thyroid disorders, we studied the cardiac performance and assessed serum levels of thyroid hormones and Coenzyme Q10 in 20 patients with hyperthyroidism, 5 patients with hypothyroidism and 10 normal subjects. A significant inverse correlation between thyroid hormones and Coenzyme Q10 levels was found by performing partial correlation analysis. Because low serum levels of Coenzyme Q10 were found in thyrotoxic patients and congestive heart failure may occur as a result of severe hyperthyroidism, 120mg of Coenzyme Q10 was administered daily for one week to 12 hyperthyroid patients and the change in cardiac performance was assessed. Further augmentation of cardiac performance was found in hyperthyroid hearts, which were already augmented, after the administration of Coenzyme Q10. It appears, therefore, that the Coenzyme Q10 dose actually has a therapeutic value for congestive heart failure induced by severe thyrotoxicosis.

Information related to the author
© The Japan Endocrine Society
Previous article Next article
feedback
Top