Bioconversion of Arachidonic Acid to Prostaglandins and Related Compounds in Human Myometrium and Uterine Cervix

Abstract

Arachidonic Acid metabolites in human myometrium and uterine cervix were studied using silicic acid column chromatography, thin layer chromatography, reversed phase partition chromatography and gas-liquid chromatography. Myometrium produced 6-ketoPGF_1α, PGF_2α, PGE₂, thromboxane B₂. Uterine cervix produced 6-ketoPGF_1α, PGF_2α, PGE₂, thromboxane B₂, and one hydroxyacid. There was no difference between the rate of conversion of prostaglandins in myometrium and cervix. But only cervix could convert arachidonic acid to hydroxyacid.