Abstract
I131 labclled monoiodotyrosine of high specific activity was incubated with the slices and the homogenates prepared from liver, kidney and thyroid of rats. Metabolic products of monoiodotyrosine was analized by using of paperchromatography.
Liver and kidney slices well metabolized monoiodotyrosine and behaved to convert monoiodotyrosine into inorganic iodide and three unknown compounds. The ratio of radioactivity of these metabolic products to the total radioactivity had various alteration under the presence of arsenite or dinitrophenol.
Liver and kidney homogenates slightly metabolized monoiodotyrosine. A sort of metabolic products in homogenates was similar to that in slices and these radioactivity increased in the presence of a-ketoglutarate.
Thyroid slices metabolized monoiodotyrosine and converted monoiodotyrosine only into inorganic iodide.
Muscle slices never metabolized monoiodotyrosine.
