Abstract
A definite daily dose of calcium mesoxalate was orally given to rats, and to young and adult dogs, for long periods and change in pancreatic insulin content was investigated.
1. When 100mg/kg of calcium mesoxalate was daily given to rats for 1, 3, and 6 months, pancreatic insulin content was increased, most prominently in the 3 months group, becoming 1.5 times that of the control.
2. When daily doses of 10mg/kg and 50mg/kg of calcium mesoxalate were given to young dogs for 2 months pancreatic insulin content was increased to 2 times the control level, without any difference by sex.
3. When daily doses of 50mg/kg and 200mg/kg of calcium mesoxalate were given to adult dogs for 1 and 2 months, pancreatic insulin content was increased in the groups of the both doses for 1 month, especially prominently in the group of 200mg/kg for 1 month, attaining 2.5 times the control level. However, there was no difference from the control in the group of 50mg/kg for 2 months.
