Abstract
Capillary resistance, plasma and urinary pepsinogen, and urine volume were determined in eight healthy young males, when they were treated with saline (S), chlorpromazine (CP), adrenaline (A), noradrenaline (NA), CP+A, and CP+NA. The resuts were as follows:
1. S and CP did not affect capillary resistance, while both A and NA raised it twice with an intervening fall. The first rise with A was lost by combination with CP, whereas the first rise with NA was not lost by combination with CP. This fact implies strongly that A and NA act differently on the peripheral vascular system, and also that certain catabolites of A and NA might participate in the second rise in capillary resistance.
2. A increased uropepsin excretion, but NA decreased it. However, neither A nor NA had any influence upon plasma pepsinogen. CP checked and delayed the initial rise in uropepsin with A, but CP+NA increased it in contrast to the effect of NA administration alone. CP did not affect urinary pepinogen, while it greatly raised urine volume. Both A and NA apparently counteracted the diuretic action of CP, although A seemed more effective than NA in this measure.
