THE EFFECT OF SPLANCHNIC NERVE STIMULATION ON ADRENOCORTICAL SECRETION

Abstract

Secretion of 17-hydroxycorticosterone and corlicosterone from adrenal venous blood of a dog was investigated using Bush's benzene-methanol-water system of paper chromatography. Stimulation of splanchnic nerve resulted in a significant increase of 17-hydroxycorticosterone and decrease of corticosterone resulting in a marked increase of F/B ratio. This effect was abolished by hypophysectomy and restored by maintenance with ACTH. Stimulation of 17-hydroxylation in adrenal cortical hormone biosynthesis is suggested as the mechanism of splanchnic nerve action.