ÜBER DIE WIRKUNG VON KALHKREIN AUF DIE FUNKTION DES HYPOPHYSE-GONADENSYSTEMS
1962 Volume 9 Issue 2 Pages 81-89
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1962 Volume 9 Issue 2 Pages 81-89
The effect of kallikrein on the pituitary-gonadal function was investigated in rats.
In female rats the ovarian and uterine weights showed a significant increase after 30 day kallikrein treatment.Adrenal and thyroid weights and tail length increased significantly only in a few sections of the experiments. No change in 131I uptake and T/S ratio of the thyroid was noted.
In male rats only the prostate and seminal vesicles showed a significant weight gain but not the other organs.
In hypophysectomized rats the weights of ovary, uterus, adrenals and thyroids were not significantly different between the kallikrein administered group and the control.
Pituitary gonadotrophic potency as measured by the mouse-uterine-weight method was augmented by kallikrein both in female and male rats.
It seems reasonable to conclude from these results that kallikrein has an effect to augment the production and release of pituitary gonadotrophin.
