Objectives: This study aims to clarify whether work engagement mediates the relationship between job resources (i.e., supervisor support, coworker support, and job control) and work-to-family positive spillover (WFPS) for home-visiting nursing staff. Methods: This cross-sectional study surveyed 15 male and 152 female participating home-visit nursing staff across 108 home-visit nursing stations in Fukuoka Prefecture, Japan. In February 2019, each participant provided informed consent and sociodemographic information, and answered three scales, including the short-form version of the Utrecht Work Engagement Scale in Japanese, the Japanese version of the Survey Work-Home Interaction – Nijmegen (J-SWING), and the Job Content Questionnaire (JCQ-22). We evaluated supervisor support, coworker support, and job control as job resources using the JCQ-22's subscale. We then evaluated WFPS using the J-SWING's subscale. The hypothesized model was then tested using structural equation modeling. Results: Job resources were positively related to work engagement among the home-visit nursing staff; in turn, work engagement was positively related to WFPS. Job resources had no significant relationship with WFPS. These results suggest that work engagement mediates the relationship between job resources and WFPS. Conclusions: This study found that job resources were not directly related to WFPS for home-visit nursing staff. However, work engagement mediated the relationship between job resources and WFPS.