Initial Arthritic Lesions Induced by Immunization with Type II Collagen in Lewis Rats

Masakazu TAKESHITA; Hiromi HINOUE; Osamu FURUKAWA; Isao TAKATA

doi:10.1538/expanim.44.63

Experimental Animals

Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124

Note

Initial Arthritic Lesions Induced by Immunization with Type II Collagen in Lewis Rats

Masakazu TAKESHITA, Hiromi HINOUE, Osamu FURUKAWA, Isao TAKATA

著者情報

キーワード: arthritic lesions, rat, type II collagen

ジャーナルフリー

1995 年 44 巻 1 号 p. 63-66

DOI https://doi.org/10.1538/expanim.44.63

詳細

抄録

11Lewis rats were immunized with an intradermal injection of type II collagen to study the time course of arthritic lesions. Serum type II collagen antibody was detected 9 days after immunization. Increased paw volume in the hind limbs was noted on day 11. Histopathologically, proliferation of synovial lining cells was observed on day 11 and typical lesions similar to those of human rheumatoid arthritis were noted on day 18.