Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Note
Initial Arthritic Lesions Induced by Immunization with Type II Collagen in Lewis Rats
Masakazu TAKESHITAHiromi HINOUEOsamu FURUKAWAIsao TAKATA
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ジャーナル フリー

1995 年 44 巻 1 号 p. 63-66

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11Lewis rats were immunized with an intradermal injection of type II collagen to study the time course of arthritic lesions. Serum type II collagen antibody was detected 9 days after immunization. Increased paw volume in the hind limbs was noted on day 11. Histopathologically, proliferation of synovial lining cells was observed on day 11 and typical lesions similar to those of human rheumatoid arthritis were noted on day 18.

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© 1995 Japanese Association for Laboratory Animal Science
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