Chromosomal Localization of a Strain-Specific p53-Related Sequence in Rat (Rattus norvegicus)

Tetsuo KUNIEDA; Eiji KOBAYASHI; Hiroshi IKADAI; Tomonori IMAMICHI

doi:10.1538/expanim.44.301

Abstract

Strain-specific restriction fragments hybridizing to human p53 gene cDNA, which was detected in only particular strains of inbred rat were revealed by Southern blot hybridization of DNAs of various inbred rat strains. Chromosomal location of the strain-specific fragments was determined on rat chromosome 1 between Kal and Pkc loci by linkage analysis using microsatellite marker loci. The fragments were concluded to be a novel p53-related sequence which is present in particular rat strains and absent from the remaining strains.

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