Globule Leukocytes in Transitional Cell Hyperplasia and Carcinomas of Aged Mice

Abstract

Globule leukocytes (GLs) infiltrating in transitional cell hyperplasia and carcinomas of aged BDF₁ mice were pathologically examined. The intracytoplasmic granules of globule leukocytes showed a variety of reactivity to histochemical staining for polysaccharides and were ultrastructurally composed of homogeneous electron dense material, occasionally containing crystaloids or vesicles. The GL infiltrating in tumor tissue is extremely rare.