Chromosomal Mapping of Human Angiotensinogen Gene and Human Renin Gene by Fluorescence In Situ Hybridization (FISH) in Transgenic Mice

Yuka WATANABE; Michi EBUKURO; Ken-ichi YAGAMI; Fumihiro SUGIYAMA; Junji ISHIDA; Kazuo MURAKAMI; Tatsuji NOMURA; Hideki KATOH

doi:10.1538/expanim.45.265

Note

Chromosomal Mapping of Human Angiotensinogen Gene and Human Renin Gene by Fluorescence In Situ Hybridization (FISH) in Transgenic Mice

Yuka WATANABE, Michi EBUKURO, Ken-ichi YAGAMI, Fumihiro SUGIYAMA, Junji ISHIDA, Kazuo MURAKAMI, Tatsuji NOMURA, Hideki KATOH

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Keywords: FISH, human angiotensinogen gene, human renin gene, mapping, PCR, Tsukuba hypertensive mouse

JOURNAL OPEN ACCESS

1996 Volume 45 Issue 3 Pages 265-269

DOI https://doi.org/10.1538/expanim.45.265

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Abstract

We attempted to apply FISH to chromosomal mapping of the human angiotensinogen (hAG) and human renin (hRN) transgenes which are carried by the parental strains of the Tsukuba hypertensive mouse. We report here that the hAG gene is mapped in the C2 region of Chr 19 and the hRN gene in the A1 region of Chr 6.

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