Experimental Animals
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The Production of Arthritis in Beagles by an Immunological Reaction to Bovine Serum Albumin
Fumihito OHASHITerumasa SHIMADAMasahiko SAKURAISeiko ISHIHARAMitsuru KUWAMURAJoji YAMATEMituaki OTA
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Volume 45 (1996) Issue 4 Pages 299-307

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Abstract

Arthritis was produced in beagles by the immunological reaction to bovine serum albumin (BSA). Dogs immunized with BSA showed the development of delayed type-hypersensitivity response to BSA and the significant increase in the titer of serum anti-BSA antibodies. The development of arthritis and the increase in a number of nucleated cells in synovial fluid were observed by the injection with BSA into the knee joints of immunized dogs. The synovial membrane of BSA-injected joints revealed a remarkable villous hyperplasia of membrane, and an infiltration of lymphocytes and plasma cells around vessels, resulting in a lymphoid nodule-like formation. The depositions of IgG and C3 on the surface of the synovial membrane were also observed in BSA-injected joints. Histopathological and immunopathological findings indicated that the immune response to BSA in the knee joints could induce a rheumatoid arthritis like chronic synovitis in dogs.

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© 1996 Japanese Association for Laboratory Animal Science
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