Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Original
Extension of Conserved Regions in the Rat and Mouse Genomes by Chromosomal Assignments of 29 Rat Genes
Zonghu CUINorihide YOKOITakashi KURAMOTOKazuhiro KITADATadao SERIKAWA
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JOURNALS FREE ACCESS

1998 Volume 47 Issue 2 Pages 83-88

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Abstract

We recently constructed a comparative genetic map of the rat, mouse and human genomes based on information obtained from several databases. In this study, we performed chromosomal assignments of 29 rat genes with somatic cell hybrid clones, in order to clarify and extend the conserved regions in the rat and mouse genomes. As a result, the conserved regions were extended by 89 cM. Together with our previous report, the length of the conserved regions in the rat and mouse spans 847 cM on the mouse linkage map, indicating that 53% of the mouse genome is covered by homologous regions in the rat. In addition, four conserved regions were newly revealed. The method described in this study appears to be simple and efficient for constructing a whole genome comparative map of the rat and mouse.

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© 1998 Japanese Association for Laboratory Animal Science
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