Vascular Remodeling in Hypertensive Transgenic Mice

Naomi NISHIJO; Shoko TAKAMINE; Fumihiro SUGIYAMA; Koichi KIMOTO; Keiko TANIGUCHI; Hisashi HORIGUCHI; Takesaburo OGATA; Kazuo MURAKAMI; Akiyoshi FUKAMIZU; Ken-ichi YAGAMI

doi:10.1538/expanim.48.203

Note

Vascular Remodeling in Hypertensive Transgenic Mice

Naomi NISHIJO, Shoko TAKAMINE, Fumihiro SUGIYAMA, Koichi KIMOTO, Keiko TANIGUCHI, Hisashi HORIGUCHI, Takesaburo OGATA, Kazuo MURAKAMI, Akiyoshi FUKAMIZU, Ken-ichi YAGAMI

Author information

Naomi NISHIJO
Laboratory Animal Research Center, University of Tsukuba
Tokyo Kasei University
Shoko TAKAMINE
Laboratory Animal Research Center, University of Tsukuba
Fumihiro SUGIYAMA
Laboratory Animal Research Center, University of Tsukuba
Center for Tsukuba Advanced Research Alliance, University of Tsukuba
Koichi KIMOTO
Tokyo Kasei University
Keiko TANIGUCHI
Laboratory Animal Research Center, University of Tsukuba
Hisashi HORIGUCHI
Ibaraki Prefectural University of Health Sciences
Takesaburo OGATA
Ibaraki Prefectural University of Health Sciences
Kazuo MURAKAMI
Center for Tsukuba Advanced Research Alliance, University of Tsukuba
Institute of Applied Biochemistry, University of Tsukuba
Akiyoshi FUKAMIZU
Center for Tsukuba Advanced Research Alliance, University of Tsukuba
Institute of Applied Biochemistry, University of Tsukuba
Ken-ichi YAGAMI
Laboratory Animal Research Center, University of Tsukuba

Keywords: hypertension, transgenic mice, vascular remodeling

JOURNAL FREE ACCESS

1999 Volume 48 Issue 3 Pages 203-208

DOI https://doi.org/10.1538/expanim.48.203

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Abstract

We physiologically and histopathologically analyzed vascular damage due to hypertension and vascular remodeling in hypertensive transgenic mice (Tsukuba hypertensive mice; THM). Pubertal (6-week-old) THM already had hypertension similar to blood pressure in adult THM due to an enhanced renin angiotensin system (RAS). They progressively developed remarkable vascular hypertrophy composed of dedifferentiation of vascular smooth muscle cells (VSMCs) and extracellular matrix accumulation in the thoracic aorta, and VSMC hyperplasia was predominant in the abdominal aorta. THM are therefore a useful animal model for studying vascular remodeling mediated by enhanced RAS.

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