Spontaneous Neoplastic Lesions in Aged Sprague-Dawley Rats

Motokuni NAKAZAWA; Takeharu TAWARATANI; Hiroshi UCHIMOTO; Akitaka KAWAMINAMI; Makoto UEDA; Akiko UEDA; Yasuhiko SHINODA; Keiko IWAKURA; Kohei KURA; Nobuyoshi SUMI

doi:10.1538/expanim.50.99

Original

Spontaneous Neoplastic Lesions in Aged Sprague-Dawley Rats

Motokuni NAKAZAWA, Takeharu TAWARATANI, Hiroshi UCHIMOTO, Akitaka KAWAMINAMI, Makoto UEDA, Akiko UEDA, Yasuhiko SHINODA, Keiko IWAKURA, Kohei KURA, Nobuyoshi SUMI

Author information

Motokuni NAKAZAWA
Research Laboratories, Nippon Shinyaku Co., Ltd.
Takeharu TAWARATANI
Research Laboratories, Nippon Shinyaku Co., Ltd.
Hiroshi UCHIMOTO
Research Laboratories, Nippon Shinyaku Co., Ltd.
Akitaka KAWAMINAMI
Research Laboratories, Nippon Shinyaku Co., Ltd.
Makoto UEDA
Research Laboratories, Nippon Shinyaku Co., Ltd.
Akiko UEDA
Research Laboratories, Nippon Shinyaku Co., Ltd.
Yasuhiko SHINODA
Research Laboratories, Nippon Shinyaku Co., Ltd.
Keiko IWAKURA
Research Laboratories, Nippon Shinyaku Co., Ltd.
Kohei KURA
Research Laboratories, Nippon Shinyaku Co., Ltd.
Nobuyoshi SUMI
Research Laboratories, Nippon Shinyaku Co., Ltd.

Keywords: rats, spontaneous tumor, Sprague-Dawley

JOURNAL OPEN ACCESS

2001 Volume 50 Issue 2 Pages 99-103

DOI https://doi.org/10.1538/expanim.50.99

Details

Abstract

Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.

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