Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
Original
Spontaneous Neoplastic Lesions in Aged Sprague-Dawley Rats
Motokuni NAKAZAWATakeharu TAWARATANIHiroshi UCHIMOTOAkitaka KAWAMINAMIMakoto UEDAAkiko UEDAYasuhiko SHINODAKeiko IWAKURAKohei KURANobuyoshi SUMI
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Volume 50 (2001) Issue 2 Pages 99-103

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Abstract

Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.

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© 2001 Japanese Association for Laboratory Animal Science
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