Spontaneous Neoplastic Lesions in Aged Sprague-Dawley Rats

Motokuni NAKAZAWA; Takeharu TAWARATANI; Hiroshi UCHIMOTO; Akitaka KAWAMINAMI; Makoto UEDA; Akiko UEDA; Yasuhiko SHINODA; Keiko IWAKURA; Kohei KURA; Nobuyoshi SUMI

doi:10.1538/expanim.50.99

Original

Spontaneous Neoplastic Lesions in Aged Sprague-Dawley Rats

Motokuni NAKAZAWA, Takeharu TAWARATANI, Hiroshi UCHIMOTO, Akitaka KAWAMINAMI, Makoto UEDA, Akiko UEDA, Yasuhiko SHINODA, Keiko IWAKURA, Kohei KURA, Nobuyoshi SUMI

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Keywords: rats, spontaneous tumor, Sprague-Dawley

JOURNAL OPEN ACCESS

2001 Volume 50 Issue 2 Pages 99-103

DOI https://doi.org/10.1538/expanim.50.99

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Abstract

Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.

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